Post-Translational Modification Functional Analysis Service
Post-translational modifications are essential regulators of protein structure and function. They influence signaling pathways, metabolic activity, protein interactions, and disease processes. With nearly two hundred PTM types identified, large-scale proteomics now produces enormous datasets that require careful interpretation. Simply detecting PTMs is not enough. Researchers need functional insights to understand what these modifications mean for biological pathways and cellular regulation.
Figure 1. Post-Translational Modification Functional Analysis
MtoZ Biolabs offers a post-translational modification functional analysis service to bridge this gap. By integrating advanced proteomics data with pathway mapping, enrichment analysis, and network visualization, we help researchers translate complex PTM datasets into meaningful biological conclusions.
Services at MtoZ Biolabs
Our post-translational modification functional analysis service provides a complete interpretation pipeline for PTM studies. Using high-quality mass spectrometry data combined with curated databases and statistical tools, we deliver actionable results that connect modifications to biological processes.
1. PTM Annotation: Annotation of modification sites with information on protein domains, motifs, and structural elements.
2. Functional Enrichment:
3. Protein Interaction and Network Analysis:
4. Co-modification and Crosstalk Analysis:
5. Pathway Mapping:
6. Quantitative Data Integration:
Service Advantages
1. Comprehensive and Integrated Analysis
We deliver end-to-end post-translational modification functional analysis service that begins with high-resolution mass spectrometry data and extends through functional annotation, enrichment analysis, and network visualization. This ensures that modifications are not only identified but also interpreted in their biological context.
2. Advanced Instrumentation and Expertise
Our laboratory is equipped with state-of-the-art LC-MS/MS platforms including Orbitrap Fusion Lumos and Q Exactive HF systems. Combined with an experienced scientific team, we provide sensitive detection and confident localization of modification sites.
3. Robust Bioinformatics Support
We apply curated databases and advanced computational workflows to deliver statistically sound and biologically meaningful results. Our bioinformatics support includes visualization of networks and pathways, enrichment reports, and assistance with data interpretation.
4. Flexibility Across PTM Types
We support analysis of multiple PTM categories, including phosphorylation, ubiquitination, acetylation, methylation, glycosylation, and SUMOylation. Custom strategies are available for less common modifications, ensuring broad applicability to diverse research needs.
5. Customized Solutions and Client Support
Every project is unique. We tailor workflows to match the goals of each client, offering consultation at the design stage, updates during analysis, and expert guidance on result interpretation.
Applications
✅ Cancer research: discovery of signaling pathways and kinases linked to oncogenic regulation and therapy resistance
✅ Neurodegenerative studies: analysis of PTMs in tau, alpha-synuclein, and related proteins in Alzheimer’s and Parkinson’s disease
✅ Metabolic disorders: linking enzyme acetylation and succinylation to diabetes, obesity, and energy metabolism
✅ Cardiovascular biology: examining PTMs in contractile proteins and vascular signaling molecules
✅ Signal transduction: mapping phosphorylation cascades and ubiquitin-mediated regulation
✅ Drug development: understanding how therapeutic candidates reshape PTM landscapes and mechanisms of action
✅ Systems biology: integrating PTM data into models of cellular regulation and pathway dynamics
Deliverables
1. Experimental details and workflows
2. Raw and processed mass spectrometry data files
3. Comprehensive PTM site tables
4. Functional enrichment and pathway reports
5. Network and pathway visualizations
6. Integrated summary report
7. Bioinformatics support
Post-translational modifications control many aspects of cellular function, and functional analysis is essential to interpret their biological meaning. MtoZ Biolabs provides a post-translational modification functional analysis service that transforms complex proteomics data into clear biological insights.
Partner with us to advance your research and uncover new opportunities in protein regulation and disease biology.