Methyl-proteomics Data Analysis Service
Methyl-proteomics Data Analysis Service is dedicated to the systematic processing and interpretation of proteomics datasets to identify and quantify protein methylation events. This service provides critical insights into epigenetic regulation, chromatin remodeling, transcriptional control, and signaling pathways, highlighting the biological significance of methylation in both health and disease.
At MtoZ Biolabs, we integrate high-resolution LC–MS/MS datasets with advanced bioinformatics pipelines to deliver accurate and reproducible results. Our Methyl-proteomics Data Analysis Service is compatible with diverse input data types, including samples enriched with high-quality pan-methyl antibodies, and supports multiple quantification strategies such as TMT, iTRAQ, and label-free approaches. This ensures comprehensive coverage of lysine and arginine methylation, across mono-, di-, and trimethylation states, providing a robust foundation for biological discovery and translational research.
Services at MtoZ Biolabs
MtoZ Biolabs provides a full spectrum of methyl-proteomics data analysis options designed to meet the needs of diverse research projects:
· Raw Data Processing: File conversion, noise reduction, peak picking, and spectral calibration.
· Protein Identification: Database search with detection of lysine and arginine methylation events.
· Site Localization: Statistical validation of methylation sites with high-confidence scoring.
· Quantitative Analysis: Support for TMT, iTRAQ, and label-free workflows to profile methylation states across conditions.
· Methylation Type Resolution: Distinguishing monomethylation, dimethylation, and trimethylation on lysine or arginine residues.
· Bioinformatics Interpretation: Integration of algorithms for site-specific quantification, differential expression analysis, motif enrichment, and pathway mapping, delivered in structured visual formats.
· Cross-PTM Integration: Linking methylation data with acetylation, phosphorylation, or ubiquitination profiles for broader mechanistic insights.
If your existing data quality or interpretation is unsatisfactory, MtoZ Biolabs also offers end-to-end methyl-proteomics solutions, covering sample preparation, LC–MS/MS acquisition, and comprehensive bioinformatics analysis to guarantee accurate site identification and high-quality outputs.
Analysis Workflow
Sample/Data Submission Suggestions
MtoZ Biolabs accepts LC–MS/MS raw files (.raw, .mzML) and processed identification results. Clients are encouraged to provide details of enrichment strategies, quantification methods, and experimental design. For detailed submission guidelines, please contact our scientific team.
Why Choose MtoZ Biolabs?
✔ Advanced Technology: Expertise in analyzing high-resolution Orbitrap and Q-TOF MS data.
✔ Comprehensive Coverage: From histone methylation profiling to global non-histone protein methylation analysis.
✔ Flexible Quantification: Support for label-free and multiplexed TMT/iTRAQ strategies.
✔ In-depth Insights: From residue-level identification to functional and pathway-level annotation.
✔ One-Time-Charge: Our pricing is transparent, no hidden fees or additional costs.
Applications
· Epigenetics: Characterizing histone methylation states that regulate gene expression and chromatin structure.
· Cancer Research: Identifying methylation-dependent signaling mechanisms driving oncogenesis and drug resistance.
· Neurobiology: Investigating protein methylation in learning, memory, and neurodegenerative diseases.
· Drug Discovery: Exploring methyltransferase and demethylase enzyme activity for novel therapeutic targets.
· Precision Medicine: Profiling methylation signatures as biomarkers for disease diagnosis and prognosis.
MtoZ Biolabs’ Methyl-proteomics Data Analysis Service transforms proteomics datasets into actionable insights by providing comprehensive methylation site mapping, flexible quantification strategies, and advanced bioinformatics interpretation. By delivering high-quality and reproducible results, we enable researchers to uncover methylation-dependent regulatory mechanisms, identify potential therapeutic targets, and accelerate discoveries in both fundamental biology and translational medicine.
Contact our team today to learn how our methyl-proteomics solutions can advance your research and complement our full portfolio of post-translational proteomics analysis services.
What Could be Included in the Report?
· A comprehensive technical report with experimental details and interpretation
· Structured visual outputs including volcano plots, heatmaps, protein–protein interaction (PPI) networks, and pathway enrichment diagrams
· Identified methylation sites with localization probabilities and confidence scores
· Quantitative datasets with differential analysis across experimental conditions
· Raw and processed data files in standard formats (RAW, mzML, FASTA, Excel)