Biopharmaceutical Glycan Analysis Service
Glycosylation is one of the most common post-translational modifications of proteins and plays a critical role in the biopharmaceutical field. Compared with other modifications, glycans are more complex and diverse in structure, directly determining the physicochemical properties, pharmacokinetic characteristics, and biological functions of glycoprotein drugs. In biopharmaceuticals such as monoclonal antibodies, recombinant proteins, and vaccines, glycans not only influence stability and half-life but are also closely associated with immunogenicity, pharmacological activity, and in vivo distribution. Studies have shown that glycan heterogeneity may lead to decreased drug activity, increased immune side effects, and even compromised clinical efficacy. Therefore, biopharmaceutical glycan analysis has become an indispensable part of drug development, quality control, and regulatory submission.
Figure 1. Workflow for Biopharmaceutical Glycan Analysis
As a professional proteomics CRO, MtoZ Biolabs is committed to providing high-quality analytical services for both academic and industrial clients. Leveraging high-resolution MS platforms and well-established sample preparation workflows, our biopharmaceutical glycan analysis service systematically characterizes glycan structures and distribution patterns, helping evaluate drug consistency and compliance, and accelerating the transition from research to clinical development.
Services at MtoZ Biolabs
MtoZ Biolabs’ biopharmaceutical glycan analysis service is designed for a wide range of glycoprotein-based biopharmaceuticals including antibody drugs, recombinant proteins, and vaccines. We provide end-to-end solutions covering glycan release, separation and detection, and structural characterization.
Table 1. Biopharmaceutical Glycan Analysis Service at MtoZ Biolabs
| Glycan Release Service | Glycan Separation and Purification Services | Glycan Linkage Type Analysis Service |
| Glycan Derivatization Service | Glycan Linkage Analysis Service | Glycan Composition Analysis Service |
| Glycan Branching Analysis Service | Glycan Modification Analysis Service | Glycan Profile Analysis Service |
| Glycan Structure Analysis Service | Glycan Sequencing Service | Single Glycan Quantitative Analysis Service |
| N-glycan Analysis Service | O-Glycan Analysis Service | Glycan Analysis Service |
Service Advantages
1. Comprehensive Coverage of Glycan Types
We provide thorough analysis of both N-glycans and O-glycans. By applying multiple release and detection methods, we ensure that the analytical results are complete, reliable, and representative of the true glycosylation profile.
2. High-Resolution and High-Sensitivity Detection
With high-resolution mass spectrometry, we accurately identify subtle mass differences and detect low-abundance glycans. The integration with chromatographic and electrophoretic techniques further enhances resolution and sensitivity, ensuring reproducibility of the results.
3. Expertise in Data Interpretation and Application
Our team has extensive experience in glycan analysis of antibodies and recombinant proteins. We provide clear and actionable interpretation of the results, enabling researchers and biopharmaceutical developers to better understand the biological and pharmaceutical significance of glycan characteristics.
4. One-Stop Service
MtoZ Biolabs offers a complete workflow from sample preparation, glycan release and labeling, MS detection, to data analysis and final reporting, providing clients with an integrated one-stop glycan analysis platform.
5. One-Time Charge
Our pricing is transparent, with no hidden fees or additional costs.
Applications
✔️ Antibody drug development: Characterize Fc and other critical domains for glycan modifications, assessing their impact on drug stability, half-life, and immune effects.
✔️ Recombinant protein quality characterization: Analyze glycan structures to ensure they meet expected attributes and clinical quality requirements.
✔️ Batch-to-batch consistency evaluation: Compare glycan distributions across different production batches to ensure manufacturing stability and product consistency.
✔️ Regulatory submission support: Provide data and reports in line with regulatory guidelines to support successful registration and submission.
Glycan analysis is a core component of structural characterization and quality control in the biopharmaceutical field. It determines not only drug safety and efficacy but also directly impacts product consistency and regulatory compliance. With advanced MS platforms and extensive analytical expertise, MtoZ Biolabs delivers professional and systematic biopharmaceutical glycan analysis service that supports drug development, quality assurance, and regulatory submission.
Contact us today to obtain customized analytical solutions and make your biopharmaceutical development more efficient, precise, and compliant with international standards.